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Sequencing libraries were loaded on an Illumina HiSeq4000 flow cell at VIB Nucleomics core with sequencing settings according to the recommendations of 10x Genomics, pooled in a 85:15 ratio for the gene expression and antibody-derived libraries, respectively

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Additionally, Mounjaro , one of the newer diabetes drugs, which was approved in May 2022 and has a unique dual mechanism of action (it activates the GLP-1 hormone as well as another hormone called the glucose-dependent insulinotropic polypeptide or GIP, both helping to improve blood sugar) may be even more effective than semaglutide in reducing weight