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Establishing consistent sleep-wake times, creating a dark and cool bedroom environment, and limiting screen exposure before bed can improve sleep quality and support healthy GLP-1 activity

Thirdly, advance the development of novel saponin formulations (e.g., nanoparticle-encapsulated, receptor-targeted liposomes, pH-responsive prodrugs) and initiate phase I/II clinical trials combining these optimized formulations with standard chemotherapeutic regimens, focusing on evaluating their in vivo bioavailability, safety profiles (especially hemolytic toxicity and organ tolerance), and clinical efficacy in cancer patients, while establishing unified evaluation criteria for the therapeutic potential of saponin-based combination therapies

Patients who are particularly sensitive to GI side effects, who have a history of severe nausea with other medications, or who simply prefer a cautious approach may benefit from starting lower

Declarations Acknowledgement The authors acknowledge DST-FIST for sponsoring the Department of Biotechnology, Central University of Tamil Nadu