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By regulating the unpolymerized actin pool, TB-500 acts as a rheostat for cytoskeletal remodeling : on migration or repair signals, sequestered G-actin is released and polymerized at the leading edge of moving cells

10.1016/j.jinf.2020.03.037 101 YoshimuraR.SanoH.MasudaC.KawamuraM.TsubouchiY.CharguiJ.et al (2000)

Sustained elevated GH and IGF-1 are the pharmacologic feature

In conclusion, the authors established an effective method for monitoring AFU activity in vitro and in vivo, which could contribute to the early diagnosis and treatment of HCC

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