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There is also a trial specifically testing whether retatrutide prevents heart attacks and strokes (TRIUMPH-3, 1,800 people), and a head-to-head trial comparing retatrutide directly against tirzepatide (the active ingredient in Zepbound) under identical conditions (NCT06662383, 800 patients)

Vaginal health changes during semaglutide treatment are real, but they are not caused by the medication directly

Delivery Method Differences The primary practical difference is the delivery method

These include: Nausea (the most common complaint, particularly during dose escalation) Vomiting Diarrhoea Constipation Decreased appetite These effects are generally dose-dependent and tend to be most pronounced during the initial weeks of treatment or following a dose increase